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A Culture of Patient-Centered Healthcare Innovation

Chiara Vona — Mon, 27 Nov 2023 10:39:19 +0000

A Culture of Patient-Centered Healthcare Innovation

Scott Fleming, Global Communications & Company Reputation

Chiara Vona Mon 27/11/2023 - 11:39

In a world where scientific innovation is advancing at an unprecedented pace, it's easy to get caught up in the excitement of cutting-edge technology. However, at ��ֳ�, we think technology is only part of the innovation puzzle. ��ֳ�'s ethos is deeply rooted in the belief that innovation should revolve around the patients we serve, and we have a culture where the patient is not just the end-user, but the beginning and the centerpiece of every breakthrough. Patient-centricity is at the heart of everything we do.

Greater Knowledge and Deeper Understanding

At ��ֳ� we ensure that each stage of the discovery and development journey is dedicated to comprehending the unique challenges faced by patients, and subsequently, providing solutions that enhance their quality of life. How? By being data-driven and question-led. By seeking a deep understanding of a disease and its underlying pathobiology. By exploring new pathways and approaches and being unafraid to take risks and challenging the status quo.

Unlocking Disease Drivers Fuels Innovation

A better understanding of a disease, its drivers and its pathobiology greatly enhances drug discovery by providing critical insights into the underlying molecular and biological factors responsible for diseases. By unravelling these intricacies, it can enable our scientists to identify specific drug targets, personalizes treatment options, and fosters biomarker discovery for diagnostics and clinical trials. Mechanism-based therapies become possible with the goal of reducing side effects and off-target impacts.
In essence, by exploring the intricate details of diseases and their pathobiology, we're not just uncovering valuable insights. We're fueling a wave of innovation in patient-centered healthcare that promises to advance patient care and public health.

Human Centric Health

At ��ֳ�, there’s one form of partnership that we’ve found to be more transformative than any other and that’s the partnership with patients. To help bring innovation to our research, we work hard to build a trusted partnership with patients. We take the time to listen and learn from patients as this provides us with insights on the personal impact of their condition. Insights that don’t come from trial data or the test tube. In fact, when you work at ��ֳ� you quickly understand that patients are not only patients but are first and foremost human beings.
It’s an empowering way to work and it sees us prioritize the individual needs, preferences, and experiences of patients. Take for example our clinical trials where many of the patients that we serve have complex conditions and our aim is to make clinical trial participation as easy as possible, enabling participants to continue with their day-to-day lives with minimal disruption. By combining patient-centered design with innovative technologies, we seek to increase flexibility and optionality.

A Home for Patient-Centered Innovation

We’ve moved away from seeing patients as just patients. By really listening and engaging with them as partners, from early research through to late-stage development, we can truly innovate, improve the patient reality and drive patient-centered healthcare.
To learn more about our culture and how innovation drives everything we do visit Innovation is | ��ֳ�.

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New approaches in epilepsy research

Vanco Vlastimil (��ֳ� S.A.) — Tue, 13 Jun 2023 11:01:22 +0000

New approaches in epilepsy research

Stefanie Dedeurwaerdere, Epilepsy Discovery Research

Vanco Vlastimi… Tue 13/06/2023 - 13:01

At ��ֳ�, we have been leaders in the research and development of treatments for epileptic seizures for more than 20 years. In 2022, more than 2.6 million people living with epilepsy benefited from our anti-seizure medications, and our commitment to providing new solutions for those in need continues. We are working towards a future where we hope to impact the underlying causes of the epilepsies with disease modifying therapies which can change the course of the disease.

It is important to recognise that there are multiple types of epilepsy. In fact, we now more commonly refer to epilepsy as the ‘epilepsies,’ indicating that it’s not really a single disease. In addition, for many people — particularly those living with certain, rare epileptic syndromes — seizures are not the only impactful symptom.

As an industry, we've been very focused on seizures, which for so many patients, continues to be top of mind. But it’s essential that, in our focus on seizure suppression, we don’t neglect what changes in the brain are often underneath those seizures.

When we understand the root cause of certain epilepsies, it opens opportunities to target the underlying mechanisms that impact these diseases, through new treatment approaches.

To further increase our understanding, we've been collaborating with universities on building one of the largest analyses of human brain tissues from epilepsy patients in the world, including > 200 samples. This in-depth study allows us to really comprehend the world of epilepsies as a global brain map, to quantify fully the different subtypes of epilepsy, understanding what they may have in common and what could be unique to specific conditions.

For complex epilepsies, where mechanisms are less understood, the situation is more challenging. Here, we are building on genetics to help understand universal disease mechanisms across the epilepsies.

In addition, we have also developed an artificial intelligence computational framework in collaboration with various academic partners to investigate disease mechanisms and processes that helps us to identify novel areas for future therapeutic entry points.

Our digital innovations are also key in allowing our patients to have a louder voice, to feel more empowered, and to know and understand their disease more thoroughly. The combination of more diverse treatment options and a more informed patient population will help bring us in an era where the treatments will be much more personalized, impacting patients’ lives in a more significant way.

Our commitment to epilepsy research has never been stronger, and as the science advances so does our curiosity. We are hopeful for the future, and we will learn and refine our thinking as we progress.

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International Clinical Trials Day: A chance to debate the future of innovation

Vanco Vlastimil (��ֳ� S.A.) — Fri, 19 May 2023 12:02:25 +0000

International Clinical Trials Day: A chance to debate the future of innovation

Iris Loew-Friedrich, Patient Value Development Solutions

Vanco Vlastimi… Fri 19/05/2023 - 14:02

Whilst markers like International Clinical Trials Day are an important moment to recognize our shared clinical challenges and opportunities, the reality is, these thoughts are never far from our mind. At ��ֳ�, one of our biggest drivers is our mission to enhance and evolve our clinical capabilities to bring life-changing innovations to our patients.

What International Clinical Trials Day does is allow us an opportunity to raise our heads above the everyday and take stock of our longer-term ambitions for clinical innovation. As a scientist, I relish the opportunity to look towards the future, and provide my insights on some of the most fundamental changes we’re striving towards, in and out of the lab.

The power of data

A key focus area is the evolution in our understanding of the power of data globally, increasing the types of data we can examine, from basic science to healthcare resource utilization information. The sharing of data could be understood as a universal drive to improve medical science. And whilst every citizen would feel a commitment to contribute data, companies, academia and government institutes would sign up to a global obligation to maximize the use of data in a responsible way for the benefit of all.

Patient experience prioritization

From the patient perspective, I see the way we design trials changing for the benefit of the participants, mirroring daily clinical practice as much as possible to ensure a diverse population can participate. Transitioning from everyday healthcare to participation in a clinical study will be seamless in the future and provide an identical experience so that clinical studies are fully integrated into care. Currently, only 5% of potentially eligible patients participate in clinical studies and this challenge is slowing down innovation. Integration of clinical studies into care will change this. Study protocols will be designed with patient needs and patient burden as the first consideration, with regulatory requirements and scientific curiosity following this priority. Patients should be able to participate from home, submitting results digitally with real-time communication and support to maximising efficiency and patient experience, and minimise the cost and carbon footprint of large-scale trials.

A truly virtualized approach

The increase of virtualized trials can further address clinical challenges, reducing the need for large patient enrolment. Artificial intelligence tools and data assets collected in one digital library could combine current patient data with historical information from earlier trials to enable robust testing with a limited cohort.

Safety-centric monitoring

Safety data could also be measured in a constant and standardized manner across the industry. Apps validated by independent scientific groups, approved by regulators and usable across all clinical studies could mean that all data related to a medicine and its control group are routed in real-time to an independent data monitoring committee. At pre-defined milestones, analyses could be performed and communicated to the clinical team and regulators, improving regulatory science and decision making.

A culture of collaboration

From a regulatory standpoint, I hope that a culture of partnership will continue, that interactions with regulatory agencies are frequent, collaborative, with transparent sharing of information, and joint evaluation of next steps.

With our industry and the world, we operate in constantly changing, there’s a healthy amount of educated speculation when we think about the future of clinical trials. But I have ultimate confidence that ��ֳ� will be at the forefront of the effort to evolve and improve the industry’s approach to innovation, for the benefit of the patients we serve.

Find out more about our passion for innovation here: Innovation is | ��ֳ�

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Building a culture of innovation: Fostering inclusivity and wellbeing in teams

Chiara Vona — Wed, 03 May 2023 13:16:53 +0000

Building a culture of innovation: Fostering inclusivity and wellbeing in teams

Dom Stanislaus, CMC Technical Lead

Chiara Vona Wed 03/05/2023 - 15:16

We believe that innovation is at the centre of everything we do at ��ֳ�. We constantly look to evolve and improve our science, knowledge, and capabilities to help us continuously innovate. But beyond the science, ��ֳ� works hard to build a culture where colleagues feel supported, valued, and able to achieve great things.

To create a culture in which inspiration and innovation can flourish, it’s essential to nurture our colleagues, and prioritize the well-being of individuals in all aspects of their lives, including at work and at home. Beyond our role as scientists and colleagues, we are so much more. To allow us to truly succeed, ��ֳ� fosters a holistic approach where we are supported as fathers, daughters, sisters, and individuals and can be our entire selves at work.

I consider myself to be incredibly lucky to work somewhere where collaboration is embedded into the fabric of everything we do. Every day I collaborate with extraordinary people in my team and with other teams across ��ֳ� who are committed to pushing the boundaries of what is possible. This culture of collaboration is integral to pushing through the difficult problems on the edge of scientific knowledge to make new breakthroughs that ultimately lead to better outcomes for patients.

Not only does ��ֳ� give space and support which makes innovation possible, but also values the importance of diversity and inclusion. To truly innovate it is essential to unlock the intellectual power of a diverse workforce. We strive to bring life-changing medicines to communities all over the world and to maximise value for patients. So, it’s vital that we see ourselves in those we serve and that our patients see themselves in us.

When people feel supported, trusted, and recognized, we can push science to the limit and beyond. By cultivating the right culture, we can unleash the potential for innovation and creativity that lead to great discoveries.

To learn more about how innovation drives everything we do visit Innovation is | ��ֳ�

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Patient perspectives on publishing research outcomes

eCMSadmin — Wed, 17 Jun 2020 00:00:00 +0000

Patient perspectives on publishing research outcomes

Alexandra Moutet, Patient Engagement

eCMSadmin Wed 17/06/2020 - 02:00

At ��ֳ�, we strive to put patients first in everything we do. This means integrating patients into all the activities along the development lifecycle to meet their needs and expectations more effectively.

A natural extension of this approach to research and innovation is to involve patients in the dissemination of our research. With this in mind, ��ֳ� is embracing an innovative way of shaping our publication planning process.

We have worked with patient partners, publication professionals and our internal experts to devise a framework for establishing Patient Publication Steering Committees (PPSCs). The feasibility of developing a PPSC was shared at the DIA Annual Meeting held virtually from June 14-18.

The purpose of the PPSC is to plan and oversee the timely and ethical development of high-quality publications that address unmet and important information needs, as identified by people with the experience of living with specific diseases. This could relate, for example, to disease burden and the patient healthcare journey. It is an approach that ensures the patient voice is heard at every stage of development.

“Establishing a PPSC can help guide who should be involved in the development of the publications and where they should be disseminated, to ensure maximum reach to relevant audiences” explained Trishna Bharadia, Patient Engagement consultant involved in the development of the framework.

We have now established the criteria for selecting PPSC members, developed a draft PPSC charter defining roles and responsibilities, drafted operational documents, and identified suitable therapeutic areas for a pilot. The documents adhered to plain language principles, met readability targets, and were deemed suitable for patients.

Our first PPSC will help to complete the co-creation of key governance and operational documents. This will provide the foundation from which our PPSC can build a publication plan that will identify topics, timelines, target conferences and journals to maximise the impact of our patient-centred scientific work.

At ��ֳ�, we see PPSCs as one of the next steps in our journey to deliver patient value. They will strengthen our commitment to patient communities by involving them in our efforts to meet their needs and expectations more efficiently. We hope this innovative step forward will contribute to writing the next chapter in the history of patient-centred care.

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DIA PPSC patients Patient Publication Steering Committee

Comment:

Posted by Peter Bates, 21 June 2020

This looks good, but I am not entirely clear about the reach of the PPSC. Is it narrowly focused on patient-facing publications, leaving all publications targeted at healthcare professionals, funders and researchers beyond it's remit?

Posted by ��ֳ�

Many thanks for your inquiry. The remit of the PPSC will be to co-create a Publication Plan based on non-product specific publications such as manuscripts on disease burden, unmet need and the patient journey, however the audience will include HCPs, funders and researchers as the manuscripts will be published in the peer-reviewed medical literature.

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Research transparency adds value for patients

eCMSadmin — Fri, 31 Jan 2020 00:00:00 +0000

Research transparency adds value for patients

Chris Pfitzer, Global Clinical Science & Operations

eCMSadmin Fri 31/01/2020 - 01:00

��ֳ� strives to improve the lives of people with severe diseases. One way we can contribute to scientific understanding is to share information about our clinical and observational research.

We have developed a new policy setting out what, when, how and where we share information about our research with patients and the public. This will help patients to make informed decisions, while also supporting future clinical research.

We see this revamped policy as a win-win for patients and researchers. Patients and their caregivers will have access to more data than ever before. This can be used to make informed decisions about their healthcare options. It reflects a wider shift towards greater patient empowerment, helping people with severe diseases become active partners in managing their conditions.

��ֳ�’s new policy also supports scientific research. Sharing individual patient-level data, in a secure way, allows for better research decisions. This in turn translates into faster and improved insights. These results drive scientific discover. Ultimately this supports our shared goal of improving the lives of patients.

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patients

A Culture of Patient-Centered Healthcare Innovation

Greater Knowledge and Deeper Understanding

Unlocking Disease Drivers Fuels Innovation

Human Centric Health

A Home for Patient-Centered Innovation

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New approaches in epilepsy research

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International Clinical Trials Day: A chance to debate the future of innovation

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Building a culture of innovation: Fostering inclusivity and wellbeing in teams

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Patient perspectives on publishing research outcomes

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Research transparency adds value for patients

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